Worsening Comorbidities

PATIENTS WITH HYPERCORTISOLISM HAVE AN INCREASED RISK FOR COMORBID CONDITIONS1,2

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A systematic review and meta-analysis of 32 studies

Reported outcomes from 4121 patients (over a median of 4 years) with adrenal incidentalomas.1

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Worsening type 2 diabetes (T2D) and hypertension1

Patients with hypercortisolism experienced worsening comorbidities compared to patients with nonfunctioning adenomas.

WORSENING Comorbid Conditions

Chart depicting worsening comorbid conditions in patients with hypercortisolism.
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A 15-year, retrospective, single-center study analyzed 198 consecutive patients with adrenal adenomas.

Patients were grouped based on their dexamethasone suppression test (DST) cortisol levels at baseline and at study end.2

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Increased risk of cardiovascular disease2

Patients with worsening DST ≥1.8 μg/dL had a 4x higher incidence of cardiovascular disease than those patients with DST <1.8 μg/dL

Cardiovascular Disease At Study End

Chart depicting cardiovascular disease at study end for patients with stable and worsening dexamethasone suppression test (DST).
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How to screen for hypercortisolism in patients with T2D

VIEW SCREENING
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Up to 10% of patients with difficult-to-control T2D may have hypercortisolism3-5

UNCOVER PREVALENCE
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References

1. Elhassan YS, Alahdab F, Prete A, et al. Ann Intern Med. 2019;171(2):107-116. doi:10.7326/M18-3630 2. Di Dalmazi G, Vivennati V, Garelli S, et al. Lancet Diabetes Endocrinol. 2014;2(5):396-405. doi:10.1016/S2213-8587(13)70211-0. 3. Chiodini I, Torlontano M, Scillitani A, et al. Eur J Endocrinol. 2005;153(6):837-844. doi:10.1530/eje.1.02045 4. Catargi B, Rigalleau V, Poussin A, et al. J Clin Endocrinol Metab. 2003;88(12):5808-5813. doi:10.1210/jc.2003-030254 5. Costa DS, Conceição FL, Leite NC, Ferreira MT, Salles GF, Cardoso CR. J Diabetes Complications. 2016;30(6):1032-1038. doi:10.1016/j.jdiacomp.2016.05.006