This portion of the website is intended for Healthcare Professionals.


For more about hypercortisolism, refer to the tools below, which include patient stories and the Endocrine Society’s Cushing’s Syndrome Diagnosis Pocket Guide.

Article summaries and highlights

article icon

Increased risk of cardiometabolic comorbidities in patients with adrenal incidentalomas with and without autonomous cortisol secretion

Yasir Elhassan, Fares Alahdab, Alessandro Prete, et al. Natural history of adrenal incidentalomas with and without mild autonomous cortisol excess. Ann Intern Med. 2019;171(2):107-116.
article icon

Cardiovascular events and mortality in patients with adrenal adenomas and excess cortisol secretion

Guido Di Dalmazi, Valentina Vicennati, Silvia Garelli, et al. Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing’s syndrome: a 15-year retrospective study. Lancet Diabetes Endocrinol. 2014;2:396-405.
article icon

Effects of cortisol levels on mortality rates in patients with adrenal adenomas

Miguel Debono, Mike Bradburn, Matthew Bull, Barney Harrison, Richard J. Ross, John Newell-Price. Cortisol as a marker for increased mortality in patients with incidental adrenocortical adenomas. J Clin Endocrinol Metab. 2014;99(12):4462-4470.
article icon

Increased cardiovascular disease risk in patients with hypercortisolism

Valentina Morelli, Giuseppe Reimondo, Roberta Giordano, et al. Long-term follow-up in adrenal incidentalomas: an Italian multicenter study. J Clin Endocrinol Metab. 2014;99(3):827-834.
article icon

Clinical approach to evaluating incidentally discovered adrenal adenomas

Anand Vaidya, Amir Hamrahian, Irina Bancos, Maria Fleseriu, Hans K. Ghayee, on behalf of the AACE Pituitary, Gonad, Adrenal, and Neuroendocrine Disease State Network. The evaluation of incidentally discovered adrenal masses. Endocr Pract . 2019;25(2):178-192.


Podcast microphone icon

Cushing’s disease and syndrome: The evolving story of hypercortisolism

In a podcast from Pituitary World News, experts discuss how the understanding of Cushing syndrome has expanded to include a variety of symptoms, disease causes, and laboratory test result ranges.

Downloadable resources

Endocrine Society Cushing’s Syndrome Diagnosis Pocket Guide

Understanding the Spectrum of Hypercortisolism Brochure

Patient stories

jenny image


Age: 33

Family: Married for more than a decade with 2 young children

Career: History major and aspiring teacher

Medical History: Thyroid nodule removal surgery, medication for symptoms; considering pituitary adenoma removal surgery

pat images


Age: 69

Family: Married for 41 years with a son and granddaughter

Career: Collegiate athletics and YMCA

Medical History: Heart attack, kidney disease

Treatment History: Medication for symptoms, heart and kidney medications, kidney removal surgery, hospitalization for fluid retention

charsetta images


Age: 47

Career: Customer service representative for a telecommunications company

Medical History: Type 1 diabetes, type 2 diabetes, hypertension, pituitary adenomas, recurrent Cushing syndrome

Treatment History: Insulin medication, antihypertensive medication, pituitary adenoma removal surgery

Nicole�s image


Age: 26

Career: Client services representative for a bovine reproduction company

Medical History: Diagnosed with multiple syndromes, disorders, and diseases prior to the diagnosis of Cushing disease

Treatment History: Bilateral adrenalectomy, steroid replacement therapy

doximity logo